What is Klonopin: How to use, Side Effects, dosage

What is Klonopin: How to use, Side Effects, dosage

What is Klonopin

Klonopin is used to treat some seizure disorders (including seizure-related absence or Lennox-Gastaut syndrome) in adults and children. Klonopin is also used to treat panic disorder (including agoraphobia) in adults.

Klonopin (clonazepam) is benzodiazepine. Clonazepam affects the brain's chemicals, which may be unbalanced. Clonazepam is also a seizure medication, also called antiviral medicines. (Read full information about clonazepam: What is clonazepam)

Clonazepam is used to prevent and control seizures. It belongs to a class of drugs called benzodiazepines.

This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Clonazepam works by calming your brain and nerves.

Please if you have any questions about Klonopin, you can ask us by commenting below this text, we'll answer you as soon as possible.

How to use Klonopin?

Swallow the tablet whole, with a full glass of water.

Do not stop taking klonopin suddenly or you could have unpleasant withdrawal symptoms, including convulsions. Ask your doctor how to safely stop using this medicine.

Dosage of Klonopin

Usual dose of klonopine for prevention of seizure:

1.5 mg orally per day is divided into 3 doses. This may increase by 0.5 to 1 mg every 3 days until the seizure is adequately controlled or until the side effects increase.

Maximum dose: 20 mg per day


The use of multiple contractions may result in increased depressive side effects.


Alone or as a supplement in the treatment of Lennox-Gastaut syndrome (Pattymele type), actinic and myoclonic seizures

Usual klonipine Adult Dose for Panic Disorder:

Initial dose: 0.25 mg oral twice daily

Maintenance dose: 1 mg per day

Maximum dose: 4 mg per day


Increased dosage for most patients may be 1 mg / day after 3 days.

The dose may be increased by 0.125 mg to 0.25 mg twice daily for 3 days until the panic disorder is controlled or until side effects increase the unwanted increase.

Administering a dose at bed time may be desirable, to reduce drowsiness discomfort.

The treatment should be stopped gradually, with a decrease of 0.125 mg twice daily every 3 days until the drug is completely removed.


Treatment of panic disorder, with or without agoraphobia

Klinopine is commonly used to diagnose seizure prevention:

Up to 10 years old or 30 kg body weight:

0.01 mg / kg / day to mg0.05 mg / kg / day orally divided into two or three doses.

10 years or more or 30 kg and more than:

See the adult dose


Daily intake should be increased from 25 to 25 mg daily to 0.5 mg per day until daily maintenance has taken, unless seizures are controlled or side effects are increased.

At any time, daily doses should be divided into three equal doses.

If the doses are not equally divided, the largest dose should be given before retirement.


Alone or as a supplement in the treatment of Lennox-Gastaut syndrome (Pattymele type), actinic and myoclonic seizures

Symptoms of over dose

Signs of administration may include severe drowsiness, confusion, muscle weakness, fatigue, or lack of work.

Symptoms of clonazepam over dosage, like those produced by other CNS depressants, include somnolence, confusion, coma, and diminished reflexes.


Side effects of Klonopin

In the case that:

New seizures or worsening

Severe drowsiness;

Abnormal changes in behavior or behavior;

Confusion, aggression, illusion.

Suicidal thoughts or hurt yourself;

Weak or shallow breathing;

Heart palpitations or vibrations in the chest; or

Unusual or unwanted eye movements.

The effects of clonazepam in older people are prolonged. Random abortions are common in older patients taking benzodiazepines. When taking clonazepam, use retention to prevent injury or damage in a timely manner.

Common side effects of Klonipine may include:

Feeling tired or depressed

Drowsiness, dizziness;

Memory problems; or

Problems with balance or coordination.

This list is not the full list of side effects and others may occur.

Drugs that may interact with Klonopin

Using this medication with other medications that causes drowsiness or slow breathing can lead to serious side effects or death. Ask your doctor before taking a sleeping pill, a narcotic drug, prescription cough medication, sedative, or medication for anxiety, depression or seizure.

Other medications may interact with clonazepam, including prescription and over-the-counter medications, vitamins and herbal products. Make sure you tell each of your health care providers about all the medications you are currently using and stop taking any drug that you start using or using.

Effects of simultaneous use of benzodiazepines and drugs

Concomitant use of benzodiazepines and drugs increases the risk of respiratory depression as a result of actions in different respiratory control CNS receptor sites. Benzodiazepines interact with GABAA sites, and opioids occur predominantly in mu receptors. When benzodiazepines and drugs are combined, benzodiazepines are likely to significantly aggravate respiration associated with respiration. Limited dose and duration of simultaneous use of benzodiazepines and opioids, and patients seeking for respiratory and sedative depression.

The effect of other drugs on the pharmacokinetics of clonazepam

Literary reports show that ranitidine, a factor that reduces gastric acidity, does not change significantly. Pharmacokinetics of clonazepam.

In a study in which 2 mg oral clonazepam tablets with propellentin (an anticholinergic agent with multiple effects on the digestive tract) were injected to healthy volunteers, the AUC of clonazepam was 10% lower and Cmax of clonazepam 20% when the fetal oral tablet with propellentin the comparison was lower when given alone.

Selective inhibitors of serotonin, sertraline (poorly induced CYP3A4) and fluoxetine (a CYP2D6 inhibitor) and anti-epileptic drugs Phalbamate (an inhibitor of CYP2C19 and CYP3A4 inhibitor) do not affect clonazepam. Cytochrome P-450 inducers, such as phenytoin, carbamazepine, lamotrigine and phenobarbital, cause clonazepam metabolism, resulting in a 38% reduction in clonazepam levels. Although clinical studies based on the interaction of the cytochrome P-450 3A family with clonazepam metabolism have not been performed, inhibitors of this enzyme system, in particular antifungal agents (eg, fluconazole) should be used with caution in patients receiving clonazepam. Because they may lead to concentrations and excessive effects of clonazepam metabolism.

Effect of clonazepam on the pharmacokinetics of other drugs

Clonazepam does not seem to change chromatasephin or phenobarbital. Clonazepam has the potential to affect the concentration of phenytoin. When taking clonazepam with phenytoin, phenytoin concentration control is recommended. The effect of clonazepam on the metabolism of other drugs has not been studied.

Pharmacodynamic interactions

CNS antidepressants from benzodiazepines may be prescribed by alcohol, drugs, barbiturates, non-barrioride drugs, anxiolytics, phenothiazines, thiouxanthene and betfenone from antipsychotics, monoamine oxidase inhibitors, and tricyclic antidepressants and other anti-inflammatory drugs. Drug seizures

Substance abuse and dependence

Controlled class

Clonazepam is a controlled substance in IV.

Physical and psychological dependence

Clonazepam withdrawal symptoms associated with symptoms are similar to those seen with barbiturates and alcohol (such as seizure, burning, hallucination, behavioral disorder, mood changes, tremor, and cramping, abdominal and muscular abdominal discomfort). More serious symptoms have been limited to people who have received too much overdose. Generally, withdrawal symptoms (dispread and insomnia) have been reported after abrupt contraction of benzodiazepines, which has been consistently treated for several months at a therapeutic level. As a result, after a long cure, sudden discontinuation should generally be eliminated and a gradual gradual reduction program should be used (see Drug and Administration). In the event of clonazepam or other psychotropic agents, due to the strength of such people in decay and dependence, people affected by food dependence (such as drug addicts or alcohol) should be monitored closely.

After short-term treatment of patients with pancreatic dysfunction in studies 1 and 2 (reviewed clinical trials), patients gradually disappear in a 7-week low-loss period (discontinuation). In general, the contraction period, with good tolerance and a very high clinical likelihood, is remarkable without evidence of redistribution. However, there is not enough data from sufficiently well-controlled long-term studies of patients with pancreatic dysfunctional clonazepam that can accurately estimate the risks of withdrawal symptoms and dependence that may be associated with such an application.

For whom Klonopin might not be safe

You should not take Klonopin if you have:

Narrow-angle glaucoma;

a history of allergic reaction to any benzodiazepine, such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), chlordiazepoxide, lorazepam, and others.

Severe liver disease; or

To make sure Klonopin is safe for you, tell your doctor if you have ever had:

Kidney or liver disease;

Asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;


Porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);

Depression or suicidal thoughts or behavior;

Mental illness, psychosis, or addiction to drugs or alcohol; or

If you use a narcotic (opioid) medication.

For children, long-term effects on physical and mental / behavioral development are unclear and may not be seen after several years. So talk about your doctor about the risks and benefits of clonazepam treatment.

Elderly adults may be more sensitive to the effects of this drug, especially drowsiness and confusion. These side effects can increase the risk of falling.

Klonopin while pregnancy

During pregnancy, this medication should only be used when needed. It may be harmful to a baby. However, since untreated seizures are a serious condition that can harm both pregnant women and their baby, do not stop taking this medication unless directed by your doctor. If you are planning to become pregnant, or you are pregnant or think you may be pregnant, talk to your doctor immediately about the benefits and risks of using this medicine during pregnancy.

Warnings of Klonopin

Do not use alcohol while taking this medicine. Clonazepam may make you habit formed. Never divide Klonopin with anyone else. Keep medication where others cannot reach it. Selling or giving this drug against the law.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.

Keep it at room temperature away from light and moisture. Do not store in the bathroom. Keep all drugs away from children and pets.


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