What is Methotrexate: How to use, Side Effects, Dosage

What is Methotrexate: How to use, Side Effects, Dosage

What is Methotrexate?

Methotrexate interferes with the growth of some cells in the body, especially rapidly-producing cells, such as cancer cells, bone marrow cells and skin cells.

Trexall (Methotrexate USP) (formerly amethopterin) is an antimetabolite used to treat some neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. Chemical Methotrexate, USP N- [4 [[(2,4-Diamino-6-pteridinyl) methyl] methyl-amino] benzoil] -L-glutamic acid.

Methotrexate is used to treat certain types of breast, skin, head and neck or lung cancer. It is also used to treat severe psoriasis and rheumatoid arthritis.

Methotrexate is a drug that is first used to treat cancer. It is now a well-known treatment for psoriasis.

Methotrexate is usually given after taking other medications without successful treatment.

Please if you have any questions about Methotrexate, you can ask us by commenting below this text, we'll answer you as soon as possible.

How to use Methotrexate?

Methotrexate is sometimes taken once or twice a week, not every day. You should use the right dosage. Some people died accidentally after taking methotrexate every day. Ask your doctor or pharmacist if you have any questions about the dose or how to use it.

Methotrexate can be toxic to your limbs and may reduce your red blood cell count. Your blood should be tested frequently and may require occasional liver biopsy. Cancer treatment may be delayed based on results.

Measure the drug fluid carefully. Use the supplied syringe dose, or use the dosage of the medication (not a kitchen spoon).

If you need calming for dental work, tell your dentist that you are currently using this medication.

Dosage of Methotrexate

Methotrexate is given orally or muscle at doses of 15 to 30 mg per day for a period of five days. These courses are usually repeated 3 to 5 times, and rest periods of one or more weeks between periods until the symptoms of the poison are known. The effectiveness of treatment is typically evaluated by 24-hour quantitative analysis of gonadotrophin urinary chorion (hCG).

Adult daily intake for acute lymphoblastic leukemia:

Induction: 3/3 mg / m 2 / day orally or in fluid (in combination with pedenison 60 mg / m 2).

Maintenance (at recovery time): 15 mg per cubic meter per day or ingestion twice a week.

Replacement dose: 2.5 mg / kg IV every 14 days.

Symptoms of over dose 

Liverurin has been shown to reduce toxicity and cure the effects of methotrexate administration. The Leviquanin administration should start as soon as possible. As the interval between Methotrexate injections and the onset of losurine increases, the effectiveness of lucauquerin in reducing disinfection is reduced. Evaluation of serum methotrexate concentration is necessary in determining the optimal dosage and duration of treatment with lucuronin.

Excessive consumption of methotrexate can be fatal.

What is Methotrexate

Please if you have any questions about Methotrexate, you can ask us by commenting below this text, we'll answer you as soon as possible.

Side effects of Methotrexate

The most common side effects are wound stomatitis, leukopenia, nausea, and abdominal disorder. Other side effects that are commonly reported include discomfort, unpleasant fatigue, chills and fever, dizziness, and reduced resistance to infection.

In the case that:

Fever, chills, swollen lymph nodes, night sweats, weight loss;

Vomiting, white patches or ulcers inside your mouth or on your lips;

Diarrhea, blood in the urine or stool;

Dry cough, mucus cough, chest pain, wheezing, shortness of breath;


Kidney problems - little or no urination, swelling in the legs or ankles;

Liver problems - Gastric pain (upper right), dark urine, jaundice (yellow skin or eyes);

Neurological problems - confusion, weakness, drowsiness, coordination problems, irritable feeling, headache, neck stiffness, vision problems, loss of movement in any part of your body; or

Symptoms of tumor failure - confusion, fatigue, numbness or tingling, muscle cramps, muscle weakness, vomiting, diarrhea, rapid or slow heartbeat, seizure.

Side effects may be greater in the elderly.

Common side effects of methotrexate may include:

Fever, chills, fatigue, not feeling well

Mouth ulcers;

Nausea, stomach upset;

Dizziness; or

Liver Non Liver Function Test.

This list is not the full list of side effects and others may occur.

Drugs that may interact with Methotrexate

Concomitant administration of some non-metabolic anti-inflammatory drugs with high methotrexate doses increased and increased serum methotrexate levels, resulting in mortality due to severe hematologic toxicity and gastrointestinal tract.

Methotrexate can damage your liver, especially if you also have some other medicines for infection, tuberculosis, depression, birth control, hormone replacement, high cholesterol, high blood pressure, heart problems, seizure, or pain or arthritis (including Acetaminophen, Tylenol, Advil, Motrin, and Aleve).

For whom Methotrexate might not be safe

If you are allergic, do not use methotrexate. Methotrexate should not be used to treat psoriasis or rheumatoid arthritis if you:

Alcoholism, cirrhosis or chronic liver disease;

A weakened immune system or bone marrow disorder; or

Low RBC count;

If you are pregnant or breastfeeding.

Sometimes methotrexate is used to treat cancer even when the patient has one of the conditions listed above. Your doctor will decide if this is the right treatment for you.

Tell your doctor about your medicine, especially:

kidney disease;

Lung disease;

Any kind of infection; or

Radiation treatments.

Warnings of Methotrexate

Methotrexate is highly toxic. Toxic effects may interfere with the frequency and intensity of the dose or frequency of use, but have been seen at all doses. Because they can occur at any time during the treatment, it is essential to follow closely patients with methotrexate. Most side reactions are reversible if detected early. When such a reaction occurs, the dose should be reduced or discontinued and corrective action should be taken. If necessary.

What is Methotrexate

Please if you have any questions about Methotrexate, you can ask us by commenting below this text, we'll answer you as soon as possible.

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