Bisoprolol: Side Effects, How to use, Dosage

Bisoprolol: Side Effects, How to use, Dosage

What is Bisoprolol?

Ziac is a combination product containing bisoprolol (zinc) and hydrochlorothiazide (HCTZ). Bioprolol is a beta-adrenergic blocking agent used to treat high blood pressure and heart pain (angina pectoris). Bioprolol prevents neurotransmitters (chemicals that the nerves communicate with other nerves), norepinephrine and epinephrine (adrenaline) from binding to beta-adrenergic receptors in the nerves. Blocking the effects of norepinephrine and epinephrine on the nerves into the heart and blood vessels, beta blockers reduce heart rate and force that stops the heart and reduces blood pressure by terminating blood vessels. It may also reduce airborne attacks by stimulating the muscles that surround the air. Hydrochlorothiazide (HCTZ) is a diuretic (a tablet of water) used to treat high blood pressure (hypertension) and fluid accumulation. This will increase urine output (diuresis) by preventing the absorption of salt and liquids in the kidneys. Its mechanism of action in lowering high blood pressure is not well understood. The combination of bisoprolol and HCTZ reduces blood pressure better than both drugs.

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How to use bisoprolol?

Take these medicines with or without food, usually once a day or as your doctor.

The dosage is based on your medical condition and response to treatment.

Use bisoprolol regularly to benefit more from it. To help you remember, put it at a time every day.

It can take several weeks to get the benefits of bisoprolol to treat high blood pressure. It is important to continue taking bisoprolol even if you feel well. Most people with high blood pressure do not feel sick.

If your condition does not improve or worsen (for example, your blood pressure remains or increases), tell your doctor.

Dosage of Bisoprolol

Bisoprolol dose should be allocated to the patient's needs. The initial starting dose is usually 5 mg once a day. In some 2.5 mg patients, a starting dose may be appropriate (see Bronchospastic Diseases in Warnings). If the antihypertensive effect of 5 mg is inadequate, the dose may be up to 10 mg and then, if necessary, 20 mg once a day.

Patients with renal or hepatic impairment

In patients with hepatic impairment (hepatitis or cirrhosis) or kidney dysfunction (creatinine measurement below 40 ml / min), the initial dose should be 2.5 mg and should be repeated in the dose. Because limited information indicates that bioprolol fumarate is not dialyz, drug replacement in dialysis patients is not necessary

Surgical patients

There is no need to adjust the dose in the elderly, unless there is a renal or hepatic dysfunction (see above and use Geriatric IN PRECAUTIONS).

Symptoms of overdose


blurred vision

cold sweats



cool, pale skin

decreased urine output


dilated neck veins

dizziness, faintness, or light-headedness when getting up from a lying or sitting position suddenly

extreme fatigue

fast heartbeat

increased hunger

irregular breathing




noisy breathing



slurred speech


swelling of face, fingers, feet, or lower legs

weight gain


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Side effects of Bisoprolol

Along with its needed effects, bisoprolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bisoprolol:

Body aches or pain

chest pain



difficult or labored breathing

ear congestion



loss of voice

nasal congestion

pain or tenderness around eyes and cheekbones

shortness of breath or troubled breathing


sore throat

stuffy or runny nose

tightness in chest

unusual tiredness or weakness


Chest discomfort

lightheadedness, dizziness, or fainting

slow or irregular heartbeat

Bisoprolol while Pregnancy

Animal models have shown toxicity, resorpuntus and abortion in doses of 50 mg / kg / day and 12.5 mg / kg / day in mice and rabbits respectively. Beta-adrenergic blocking agents have been shown to reduce the placental perfusion associated with the continuation of growth, preterm delivery and immature delivery, and fetal death. Due to limited information on bisoprolol, if a beta blocker agent is required, a beta-1 adrenoreceptor blocker may be considered. There are no controlled data in human pregnancy.

United States FDA Pregnancy Category C: Animal reproduction studies have shown adverse effects on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may be available in pregnant women, despite possible risks, if used in pregnant women.

AU TGA Category C pregnancy: Medicines that cause or may cause harm to the baby's baby or infant without anomalies due to their pharmacological effects. These effects may be reversible. Along with the texts, you should consult for more details.

Drugs that may interact with Bisoprolol

Common medications checked in combination with bisoprolol

Acetylsalicylic Acid (aspirin)




Aspir 81 (aspirin)


Aspirin Low Strength (aspirin)

Crestor (rosuvastatin)

Cymbalta (duloxetine)



Eliquis (apixaban)

Fish Oil (omega-3 polyunsaturated fatty acids)




Lasix (furosemide)

Lipitor (atorvastatin)


Lyrica (pregabalin)


Nexium (esomeprazole)

Paracetamol (acetaminophen)

Plavix (clopidogrel)


Synthroid (levothyroxine)

Ventolin (albuterol)

Viagra (sildenafil)

Vitamin B12 (cyanocobalamin)

Vitamin C (ascorbic acid)

Vitamin D3 (cholecalciferol)


Xanax (alprazolam)

Xarelto (rivaroxaban)

Warnings of Bisoprolol

Tell your doctor or pharmacist if you are allergic to bioprolol, or if you have an allergy. This product may contain inactive material that can cause allergic reactions and other problems. Talk to your pharmacist for more information.

If you have special medical conditions, bisoprolol should not be used. Before using bisoprolol, consult a doctor or pharmacist if you have severe heart failure if you are exposed to certain types of heart rhythm problems (such as slow heart beat, secondary etiologic block, or third grade).

Tell your doctor or pharmacist before taking bisoprolol: Your disease history, in particular: respiratory problems (such as asthma, chronic bronchitis, emphysema), kidney disease, liver disease, excessive thyroid disease (thyroid), reactions Serious allergic reactions include those who need to be treated with epinephrine, circulatory problems (such as rhinotracheitis, peripheral vascular disease), mental / psychiatric disorders (such as depression), a specific musculoskeletal disorder (myasthenia gravis).

If you have diabetes, this product may reduce your heart rate / heart rate, which usually affects when your blood glucose is low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness and sweating, do not affect bisoprolol. This product can also make your blood glucose control harder. Check your blood glucose regularly and share your results with your doctor. Tell your doctor if there are signs of high blood sugar such as thirst / urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Before your surgery, tell your doctor or dentist that you are taking this medication.

Bisoprolol may cause you dizziness. Alcohol or marijuana causes dizziness. Do not drive, use machines, or do anything that you need to be alert to as long as you can safely do it. Limit alcohol drinks. Talk to your doctor if you use marijuana.

During pregnancy, bisoprolol should only be needed when needed. It may be harmed to a baby. Talk with them about the dangers and benefits of the doctor.

It is unknown if the medicine leads to breast-feeding or that it may harm the infant's baby. Talk to your risk and livelihood before breastfeeding.


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